Physical Activity, Alzheimer Plasma Biomarkers, and Cognition.

ABSTRACT:

Importance

Physical activity (PA) is a nonpharmacological intervention for dementia prevention. The association between PA and Alzheimer disease (AD) plasma biomarkers remains underexplored.

Objective

To investigate the associations among PA; plasma biomarkers, including β-amyloid 42/40 (Aβ42/40), phosphorylated-tau217 (ptau217), glial fibrillary acidic protein (GFAP), and neurofilament light chain (NfL); and cognition.

Design, setting, and participants

This cross-sectional study included participants with and without cognitive impairment recruited from multiple memory clinics in South Korea between May 2019 and May 2022. Data were analyzed from June to December 2024.

Exposures

PA was assessed as metabolic equivalent task minutes per week using the Internationa

SUBMITTER: Kim SA 

PROVIDER: S-EPMC11883494 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature