Depressive Symptoms and Amyloid Pathology.

ABSTRACT:

Importance

Depressive symptoms are associated with cognitive decline in older individuals. Uncertainty about underlying mechanisms hampers diagnostic and therapeutic efforts. This large-scale study aimed to elucidate the association between depressive symptoms and amyloid pathology.

Objective

To examine the association between depressive symptoms and amyloid pathology and its dependency on age, sex, education, and APOE genotype in older individuals without dementia.

Design, setting, and participants

Cross-sectional analyses were performed using data from the Amyloid Biomarker Study data pooling initiative. Data from 49 research, population-based, and memory clinic studies were pooled and harmonized. The Amyloid Biomarker Study has been collecting data since 2012 and d

SUBMITTER: Wiels WA 

PROVIDER: S-EPMC11883504 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature