Boosting tumor homing of endogenous natural killer cells via therapeutic secretomes of chemically primed natural killer cells.

ABSTRACT:

Background

Natural killer (NK) cells play a critical role in modulating immune responses by secreting soluble factors, including chemotactic cytokines. Our previous study demonstrated the potent antitumor activity of Chem_NK, referring to NK cells chemically primed with 25 kDa branched polyethyleneimine. However, the potential of Chem_NK secretomes to educate other NK cells and enhance their tumor-homing ability remains unexplored.

Methods

The effects of Chem_NK conditioned media (Chem CM) on NK cells were evaluated in vitro by examining chemokine receptor expression and migration toward cancer cells. In vivo, the impact of Chem_NK and Chem CM on endogenous NK cell populations was assessed using xenograft and syngeneic mouse tumor models. Cytokine array and signaling analyse

SUBMITTER: Cho S 

PROVIDER: S-EPMC11883546 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature