The role of social, economic, and medical marginalization in cancer clinical trial participation inequities: A systematic review.

ABSTRACT: Extant literature reveals how patients of marginalized social identities, socioeconomic status (SES), and medical experiences - especially patients of color and older adults - are underrepresented in cancer clinical trials (CCTs). Emerging evidence increasingly indicates CCT underrepresentation among patients of lower SES or rural origin, sexual and gender minorities, and patients with comorbid disability. This review applies an intersectional perspective to characterizing CCT representativeness across race and ethnicity, age, sexual and gender identity, SES, and disability. Four databases were systematically queried for articles addressing CCT participation inequities across these marginalizing indicators, using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISM

SUBMITTER: Hanvey GA 

PROVIDER: S-EPMC11883616 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature