Experimental myositis: an optimised version of C-protein-induced myositis.

ABSTRACT:

Introduction

Inflammatory myopathies (IM) are a group of severe autoimmune diseases, sharing some similarities, whose cause is unknown and treatment is empirical.While C-protein-induced myositis (CIM), the most currently used mouse model of IM, has removed some roadblocks to understand and improve the treatment of IM, it has only been partially characterised and its generation limited by poor reproducibility. This study aimed at optimising the generation and the characterisation of CIM.

Methods

In silico analysis was run to identify the top three specific and immunogenic regions of C-protein. The cognate polypeptides were synthesised and used to immunise C57BL/6N mice. Grip strength, walking ability, serum creatine kinase levels and muscle pathology (histological and electro

SUBMITTER: Giannini M 

PROVIDER: S-EPMC11883622 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature