Curcumol promotes ferroptosis of colon cancer by targeting the ubiquitination and degradation of GPX4.

ABSTRACT:

Background and aim

Colon cancer (CC) is one of the common malignant tumors in the digestive tract, the prognosis of CC patients has never been satisfying. A Ferrous-dependent form that regulates cell death, plays a key role in cancer development. As a core regulator of ferroptosis, GPX4 has become a potential molecular target for the development of antitumor drugs. Curcumol (Cur), a sesquiterpene natural product, it has significant anti-tumor effect. However, whether Cur mediates ferroptosis in colon cancer and its mechanism are still unclear. This study aimed to investigate the underlying mechanisms of Cur anti-tumor.

Experimental procedure

By investigating the Cancer Genome Atlas (TCGA) database and tissue immunofluorescence staining was also used to detect the levels of G

SUBMITTER: Zhao W 

PROVIDER: S-EPMC11883637 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature