Guilingji capsules enhances erectile function by promoting testosterone-dependent angiogenesis in the corpus cavernosum.

ABSTRACT:

Background and aim

Guilingji capsules (GLJC) have the effect of treating erectile dysfunction (ED). This study aims to explore the potential mechanisms of GLJC in treating ED.

Experimental procedure

We conducted network pharmacology analysis of ED-related targets with GLJC components reported in the TCMSP database and GLJC components reported in the literature, respectively. Molecular docking was employed to validate the binding affinity of these molecular targets. Animal experiments were conducted to validate the aforementioned results. The mechanism of GLJC in treating ED was studied using d-galactose-induced aging rats, and orchiectomized rats were used to investigate further whether the mechanism of GLJC in treating ED is related to androgen.

Results and conclusions</

SUBMITTER: Yu X 

PROVIDER: S-EPMC11883638 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature