The impact of extent of nodal involvement on stage IIIA (N2) non-small cell lung cancer outcomes.

ABSTRACT:

Objective

Stage IIIA (N2) non-small cell lung cancer (NSCLC) treatment can depend on the extent of nodal involvement, with surgery considered for limited disease and definitive chemoradiation preferred for bulky or multi-station disease. Evidence to support management is limited. This study evaluated the impact of the extent of stage IIIA (N2) nodal involvement on outcomes after surgery.

Methods

Patients who underwent surgical resection of T1-2N2M0 NSCLC in the Surveillance, Epidemiology, and End Results database from 2004 to 2019 were stratified as having limited (1 positive node) versus more extensive (>1 positive node) nodal disease, and survival was evaluated with Kaplan-Meier and Cox analyses.

Results

Of the 6933 patients identified surgical patients, 2129 (30.7%

SUBMITTER: Wong LY 

PROVIDER: S-EPMC11883707 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature