Associations between antidepressants and risk of suicidal behavior and violent crimes in personality disorder.

ABSTRACT:

Background

Despite uncertain benefits, antidepressants are used in the management of personality disorders (PDs). We investigated the association between antidepressants and two adverse outcomes - suicidal behaviour and violent crimes - in individuals with PDs.

Methods

We used nationwide Danish healthcare registries to identify all individuals with a diagnosed PD aged 18-64 years from 2007 to 2016. Antidepressant use was identified using dispensed prescriptions. Individuals were followed up for healthcare presentations of suicidal behaviour and separately for police-recorded charges of violent crimes. We applied a within-individual design comparing rates of suicidal behaviour and violent crimes during time periods of antidepressant treatment with periods without treatment. S

SUBMITTER: Herttua K 

PROVIDER: S-EPMC11883785 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature