Adjuvant therapy for children treated by enucleation at diagnosis of retinoblastoma.

ABSTRACT:

Introduction

Advanced localized retinoblastoma can be cured by enucleation, but extraocular spread of retinoblastoma cells is associated with a high mortality. Risk-stratified adjuvant treatment with chemotherapy and radiotherapy has been shown to reduce the risk for extraocular relapse in children with histopathological risk factors.

Methods

Data of 184 patients with retinoblastoma and primary enucleation were collected in a prospective, multicenter, observational study between 2013 and 2020. The clinical characteristics were evaluated as risk factors and progression-free and overall survival rates were compared.

Results

Seventy-one percent of 184 children with retinoblastoma treated with primary enucleation were diagnosed with low risk histopathological factors (pT1

SUBMITTER: Diarra Y 

PROVIDER: S-EPMC11883903 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature