Sustainable nanophytosome-based therapies against multidrug-resistant Escherichia coli in urinary tract infections: an in Vitro and in vivo study.

ABSTRACT:

Background

Urinary tract infection (UTI) is a prevalent bacterial infection impacting a significant number of individuals globally. The rise in multidrug-resistant (MDR) E. coli strains as the predominant cause of UTIs presents a substantial public health concern and poses a challenge to existing antibiotic treatments. This study introduces an innovative and sustainable therapeutic approach utilizing rosemary oil nanophytosomes as a targeted drug delivery system to address biofilms in UTIs induced by MDR E. coli.

Method

Seventy clinically identified E. coli isolates from UTI patients were used for this study. Nanophytosomes were formulated with chitosan (CS) and nanostructured lipid carriers. CS-nanophytosomes were lyophilized to evaluate the storage stability. In vivo study

SUBMITTER: Wen MM 

PROVIDER: S-EPMC11883929 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature