Choledocholithiasis as a risk factor for cholangiocarcinoma: a nationwide retrospective cohort study.

ABSTRACT:

Background

Choledocholithiasis has been reported to be associated with the occurrence of cholangiocarcinoma (CCA); however, the association has not yet been sufficiently demonstrated. This study aimed to evaluate the association between choledocholithiasis (common bile duct stones) and CCA.

Methods

This nationwide retrospective cohort study used the Health Insurance Review and Assessment database of individuals diagnosed with choledocholithiasis between 2008 and 2009 in South Korea. Individuals were stratified by age, and CCA was categorized into extrahepatic CCA (ECA) and intrahepatic CCA (ICA). The standardized incidence ratio (SIR) was calculated to compare CCA incidence between patients with choledocholithiasis and the general population.

Results

The study enrolle

SUBMITTER: Kim J 

PROVIDER: S-EPMC11883955 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature