Association of the atherogenic index of plasma with frailty in U.S. adults: a cross-sectional study based on NHANES.

ABSTRACT:

Background

Frailty is a multifactorial syndrome associated with adverse health outcomes. The metabolic underpinnings of frailty, particularly lipid metabolism, are not fully understood. Unlike isolated lipid fractions or inflammatory markers, atherogenic index of plasma (AIP) integrates atherogenic lipid profiles and systemic inflammation. However, its association with frailty has not been extensively studied.

Methods

Six thousand four hundred participants from the National Health and Nutrition Examination Survey (NHANES) were enrolled. Frailty was calculated with the frailty index (FI), with scores ≥ 0.21 indicating frailty. Logistic regression adjusted for demographic, socioeconomic, and lifestyle factors evaluated the association between AIP and frailty. Restricted cubic

SUBMITTER: Yan S 

PROVIDER: S-EPMC11884020 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature