Unraveling the impact of frailty on postoperative delirium in elderly surgical patients: a systematic review and meta-analysis.

ABSTRACT:

Background

Frailty has been consistently implicated as a pivotal factor in the onset of delirium following anesthesia and surgery. Nonetheless, a comprehensive understanding of the relationship between frailty and delirium remains to be elucidated. This study addresses that knowledge gap.

Methods

A comprehensive search of literature databases identified 43 relevant studies involving 14,441 participants. The studies were subjected to a rigorous quality assessment using the Newcastle-Ottawa Scale. Statistical analysis was conducted using Review Manager (v5.4.1), including subgroup and sensitivity analyses.

Results

Meta-analysis revealed a significant association between preoperative physical frailty and postoperative delirium (pooled odds ratio: 2.47; 95% confidence int

SUBMITTER: Wu H 

PROVIDER: S-EPMC11884039 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature