Cost-effectiveness of universal genetic screening for familial hypercholesterolemia in young adults aged 18-40 years in China.

ABSTRACT:

Background

Mortality from familial hypercholesterolemia (FH) remains high due to late diagnosis, and the rate of timely diagnosis remains low (< 10% globally and < 1% in China). Early screening and treatment could significantly reduce mortality risk, especially among young adults. This study aims to evaluate the cost-effectiveness of universal genetic screening of young adults aged 18-40 years compared to universal cholesterol screening or current passive screening strategies (opportunistic cholesterol screening and genetic cascade testing) for FH in China.

Methods

A decision-analytic Markov model was constructed to simulate the lifetime (until 100 years old or 99% of patients died) coronary heart disease (CHD) events, discounted costs, gains in quality-adjusted life years (

SUBMITTER: Meng R 

PROVIDER: S-EPMC11884056 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature