Curcumin alleviates renal fibrosis in chronic kidney disease by targeting the circ_0008925-related pathway.

ABSTRACT:

Background

Curcumin has been shown to inhibit renal fibrosis, but whether curcumin mediates renal fibrosis progression by regulating the circular RNA (circRNA)-related pathway remain unclear.

Methods

TGF-β1 was used to construct renal injury and fibrosis cell model. Cell growth was evaluated by cell counting kit 8 assay, EdU assay and flow cytometry. Fibrosis marker and interleukin 6 signal transducer (IL6ST) protein levels were measured using western bolt analysis. Inflammation factor concentrations were determined by ELISA. Circ_0008925, miR-204-5p and IL6ST expression was assessed by qRT-PCR. Unilateral ureteral obstruction (UUO) mice models were constructed to assess the role of curcumin in vivo.

Results

Curcumin treatment alleviated TGF-β1-induced HK-2 cel

SUBMITTER: An P 

PROVIDER: S-EPMC11884099 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature