CDC20 protects the heart from doxorubicin-induced cardiotoxicity by modulating CCDC69 degradation.

ABSTRACT:

Aims

Doxorubicin (DOX) is a potent anticancer drug; however, it is associated with significant cardiotoxicity. CDC20 is an E3 ubiquitin ligase that plays a role in cell cycle progression and apoptosis in various types of cancers. The involvement of CDC20 in DOX-induced cardiotoxicity (DIC) is poorly understood. Hence, this study aimed to explore the potential role of CDC20 in the development of DIC and assess whether CDC20 influences the antitumor effects of DOX.

Methods and results

H9C2 cells were treated with DOX, followed by transcriptomic analysis to identify differentially expressed genes. C57BL/6 mice were treated with DOX for 4 weeks after tail vein injection of CDC20 myocardial-specific knockout mice, AAV9-cTNT-(si) CDC20, or intraperitoneal injection of apcin. Cardi

SUBMITTER: Feng Z 

PROVIDER: S-EPMC11884132 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature