A chimeric antigen receptor tailored to integrate complementary activation signals potentiates the antitumor activity of NK cells.

ABSTRACT:

Background

Chimeric antigen receptors (CARs) are synthetic receptors that reprogram the target specificity and functions of CAR-expressing effector cells. The design of CAR constructs typically includes an extracellular antigen-binding moiety, hinge (H), transmembrane (TM), and intracellular signaling domains. Conventional CAR constructs are primarily designed for T cells but have been directly adopted for other effector cells, including natural killer (NK) cells, without tailored optimization. Given the benefits of CAR-NK cells over CAR-T cells in terms of safety, off-the-shelf utility, and antigen escape, there is an increasing emphasis on tailoring them to NK cell activation mechanisms.

Methods

We first have taken a stepwise approach to modifying CAR components such as th

SUBMITTER: Yi E 

PROVIDER: S-EPMC11884141 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature