Investigating the role of the brain-derived neurotrophic factor Val66Met polymorphism in repetitive mild traumatic brain injury outcomes in rats.

ABSTRACT:

Background

Mild traumatic brain injury (mTBI) poses a significant public health concern, particularly regarding repetitive injury, with outcomes ranging from acute neurobehavioral deficits to long-term impairments. While demographic factors like age and sex influence outcomes, the understanding of genetic contributions, particularly the role of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism, remains limited. This study aimed to characterize acute effects of repetitive mTBI (rmTBI) in rats with the Val68Met SNP, the rodent equivalent of the human Val66Met, focusing on behavioral, fluid biomarker, and histological changes.

Methods

Using a closed-head injury model, rats underwent five mTBIs over consecutive days. Behavioral assessments included sensorimotor

SUBMITTER: Giesler LP 

PROVIDER: S-EPMC11884142 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature