Systemic inflammation partially mediates the association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and chronic cough.

ABSTRACT:

Background

Non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR), a new biomarker, reflects blood lipid status. Nevertheless, the association between NHHR and chronic cough remains uncertain.

Method

This investigation included 9725 individuals from the NHANES. This research employed multiple statistical models to illustrate the association between NHHR and chronic cough. These models included logistic regression models, the Shapley Additive Explanations (SHAP) model, trend tests, mediation analysis, restricted cubic splines (RCS), and subgroup analyses.

Result

The logistic regression model, adjusting all covariables, showed a positive association between NHHR with chronic cough (OR: 1.08; 95% CI: 1.02-1.14). Trend tests and RCS

SUBMITTER: Wang C 

PROVIDER: S-EPMC11884164 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature