Evaluation of an Innovative Rapid Diagnostic Test for Human Strongyloidiasis to Detect Specific IgG Antibody in Whole-Blood Samples.

ABSTRACT: Human strongyloidiasis is an important intestinal parasitic disease that affects public health globally and is transmitted through contact with infective larvae on contaminated soil. Immunocompromised hosts can experience hyperinfection, which can lead to fatal systemic strongyloidiasis. Here, an innovative point-of-care (POC) test kit, the strongyloidiasis immunochromatographic blood test (the NIE-SsIR whole-blood ICT) kit is described. The kit was used to detect anti-Strongyloides IgG antibody in whole-blood samples (WBSs) instead of serum to diagnose strongyloidiasis. The kit is based on a mixture of two recombinant Strongyloides stercoralis protein antigens (NIE and SsIR) and colloidal-gold-labeled conjugates of anti-human IgG antibody to evaluate diagnostic values with simulated and f

SUBMITTER: Boonroumkaew P 

PROVIDER: S-EPMC11884293 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature