A satellite cell-dependent epigenetic fingerprint in skeletal muscle identity genes after lifelong physical activity.

ABSTRACT: Satellite cells comprise a small proportion of mononuclear cells in adult skeletal muscle. Despite their relative rarity, satellite cells have critical functions in muscle adaptation, particularly during prolonged exercise training. The mechanisms by which satellite cells mediate skeletal muscle responsiveness to physical activity throughout the lifespan are still being defined, but epigenetic regulation may play a role. To explore this possibility, we analyzed global DNA methylation patterns in muscle tissue from female mice that engaged in lifelong voluntary unweighted wheel running with or without satellite cells. Satellite cells were ablated in adulthood using the tamoxifen-inducible Pax7-DTA model. Compared to sedentary mice, wheel running for 13 months caused muscle DNA methylation d

SUBMITTER: Murach KA 

PROVIDER: S-EPMC11884312 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature