Formation of rippled β-sheets from mixed chirality linear and cyclic peptides-new structural motifs based on the pauling-corey rippled β-sheet.

ABSTRACT: The rippled β-sheet is a structural motif formed by certain racemic peptides that is distinct from the commonly known pleated β-sheet. Although the structure was predicted in 1953, unambiguous crystallographic observation of a rippled β-sheet was not reported until 2022. The structural foundation of the rippled β-sheet field continues to expand, stimulating new research questions, both fundamental and applied. Recent studies found that racemic peptides of varied length and amino acid composition assemble into rippled β-sheets. Intriguingly, certain rippled sheets were found to encapsulate small molecules in ways that could become useful in drug delivery, or to trap harmful substances. These and many other potential applications hinge on the development of a comprehensive structural foundat

SUBMITTER: Hazari A 

PROVIDER: S-EPMC11884330 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature