Modulatory Neurotransmitter Genotypes Shape Dynamic Functional Connectome Reconfigurations.

ABSTRACT: Dynamic reconfigurations of the functional connectome across different connectivity states are highly heritable, predictive of cognitive abilities, and linked to mental health. Despite their established heritability, the specific polymorphisms that shape connectome dynamics are largely unknown. Given the widespread regulatory impact of modulatory neurotransmitters on functional connectivity, we comprehensively investigated a large set of single nucleotide polymorphisms (SNPs) of their receptors, metabolic enzymes, and transporters in 674 healthy adult subjects (347 females) from the Human Connectome Project. Preregistered modulatory neurotransmitter SNPs and dynamic connectome features entered a Stability Selection procedure with resampling. We found that specific subsets of these SNPs exp

SUBMITTER: Jun S 

PROVIDER: S-EPMC11884390 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature