Photothermal Coating on Zinc Alloy for Controlled Biodegradation and Improved Osseointegration.

ABSTRACT: Zinc (Zn) and its alloys are promising biomaterials for orthopedic applications due to their degradability and mechanical properties. Zn²⁺ plays a crucial role in bone formation, but excessive early release may cause cytotoxicity and inhibit osseointegration. To solve this, we developed a near-infrared (NIR) light-controlled polycaprolactone/copper-sulfur (PCL/CuS) coating that slows degradation and enhances osseointegration of Zn alloys. The zinc-lithium (Zn-Li) substrate is encapsulated with PCL, reducing Zn²⁺ release and maintaing biocompatibility. Controlled Zn²⁺ release and mild photothermal therapy via CuS nanoparticles promoted osteogenesis. In vitro studies demonstrated enhanced cell proliferation and osteogenic differentiation. In vivo Micro-Comput

SUBMITTER: Hsu Y 

PROVIDER: S-EPMC11884568 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature