M⁶A Demethyltransferase FTO Attenuates Meniscus Degeneration and Osteoarthritis via Orchestrating Autophagy and Energetic Metabolism.

ABSTRACT: Impaired autophagy is reported to promote osteoarthritis (OA). However, the mechanism by which autophagy in regulating meniscus degeneration and OA remains unclear. Here, unconvered aberrant energetic metabolism pattern in meniscus cells with OA is uncovered first, which results in lower adenosine triphosphate (ATP) production. And these phenomena are induced by impaired autophagy in meniscus cells with OA. It is further revealed that the suppression of m⁶A demethylase fat mass and obesity-associated protein (FTO) inhibits autophagy and causing lower ATP production by reducing oxidative phosphorylation. Specific deletion of FTO in meniscus cells by generating FTO^flox/flox; COL1A1-Cre^ERT2 (FTO^cko) mice impair autophagy and promote meniscus degener

SUBMITTER: Jiang Z 

PROVIDER: S-EPMC11884582 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature