Constructing Activatable Photosensitizers Using Covalently Modified Mesoporous Silica.

ABSTRACT: The combination of photosensitizers (PSs) and nanomaterials is a widely used strategy to enhance PS efficacy and broaden their applicability. However, the current nanocarrier-based delivery strategies focus on conventional PSs, neglecting the critical issue of PS phototoxicity. In this study, DHUOCl-25, an activatable PS (aPS) activated by hypochlorous acid, is synthesized by combining a silicon source structure and an activation unit. DHUOCl-25 functions as a silica source for synthesizing activatable mesoporous silica nanostrctures (MSNs) using a standardized protocol, enabling the synthesis of aPS-covalently modified MSNs for a variety of biologic therapeutic applications. On one hand, the resulting nano-aPS maintains aPS functionality for antibacterial application by achieving synergis

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11884586 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature