Scale-free Spatio-temporal Correlations in Conformational Fluctuations of Intrinsically Disordered Proteins.

ABSTRACT: The self-assembly of intrinsically disordered proteins (IDPs) into condensed phases and the formation of membrane-less organelles (MLOs) can be considered as the phenomenon of collective behavior. The conformational dynamics of IDPs are essential for their interactions and the formation of a condensed phase. From a physical perspective, collective behavior and the emergence of phase are associated with long-range correlations. Here the conformational dynamics of IDPs and the correlations therein are analyzed, using µs-scale atomistic molecular dynamics (MD) simulations and single-molecule Förster resonance energy transfer (smFRET) experiments. The existence of typical scale-free spatio-temporal correlations in IDP conformational fluctuations is demonstrated. Their conformational evolutions

SUBMITTER: Song H 

PROVIDER: S-EPMC11884614 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature