Data-driven neuroanatomical subtypes of primary progressive aphasia.

ABSTRACT: The primary progressive aphasias are rare, language-led dementias, with three main variants: semantic, non-fluent/agrammatic and logopenic. Although the semantic variant has a clear neuroanatomical profile, the non-fluent/agrammatic and logopenic variants are difficult to discriminate from neuroimaging. Previous phenotype-driven studies have characterized neuroanatomical profiles of each variant on MRI. In this work, we used a machine learning algorithm known as SuStaIn to discover data-driven neuroanatomical 'subtype' progression profiles and performed an in-depth subtype-phenotype analysis to characterize the heterogeneity of primary progressive aphasia. Our study included 270 participants with primary progressive aphasia seen for research in the UCL Queen Square Institute of Neurology D

SUBMITTER: Taylor B 

PROVIDER: S-EPMC11884653 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature