Interaction of motor behaviour, cortical oscillations and deep brain stimulation in Parkinson's disease.

ABSTRACT: Recent progress in the study of Parkinson's disease has highlighted the pivotal role of beta oscillations within the basal ganglia-thalamo-cortical network in modulating motor symptoms. Predominantly manifesting as transient bursts, these beta oscillations are central to the pathophysiology of Parkinson's disease motor symptoms, especially bradykinesia. Our central hypothesis is that increased bursting duration in cortex, coupled with kinematics of movement, disrupts the typical flow of neural information, leading to observable changes in motor behaviour in Parkinson's disease. To explore this hypothesis, we employed an integrative approach, analysing the interplay between moment-to-moment brain dynamics and movement kinematics and the modulation of these relationships by therapeutic deep

SUBMITTER: Mirpour K 

PROVIDER: S-EPMC11884658 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature