Human longevity and Alzheimer's disease variants act via microglia and oligodendrocyte gene networks.

ABSTRACT: Ageing underlies functional decline of the brain and is the primary risk factor for several neurodegenerative conditions, including Alzheimer's disease (AD). However, the molecular mechanisms that cause functional decline of the brain during ageing, and how these contribute to AD pathogenesis, are not well understood. The objective of this study was to identify biological processes that are altered during ageing in the hippocampus and that modify Ad risk and lifespan, and then to identify putative gene drivers of these programmes. We integrated common human genetic variation associated with human lifespan or Ad from genome-wide association studies with co-expression transcriptome networks altered with age in the mouse and human hippocampus. Our work confirmed that genetic variation associa

SUBMITTER: Graham AC 

PROVIDER: S-EPMC11884759 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature