Evaluation of information flows in the RAS-MAPK system using transfer entropy measurements.

ABSTRACT: The RAS-MAPK system plays an important role in regulating various cellular processes, including growth, differentiation, apoptosis, and transformation. Dysregulation of this system has been implicated in genetic diseases and cancers affecting diverse tissues. To better understand the regulation of this system, we employed information flow analysis based on transfer entropy (TE) between the activation dynamics of two key elements in cells stimulated with EGF: SOS, a guanine nucleotide exchanger for the small GTPase RAS, and RAF, a RAS effector serine/threonine kinase. TE analysis allows for model-free assessment of the timing, direction, and strength of the information flow regulating the system response. We detected significant amounts of TE in both directions between SOS and RAF, indicati

SUBMITTER: Umeki N 

PROVIDER: S-EPMC11884788 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature