More efficient, smaller multicancer screening trials.

ABSTRACT:

Background

The NHS-Galleri Trial has demonstrated feasibility of a trial design in which all participants provide a "sample" for screening, but only samples from the intervention arm are tested and acted upon during the trial. We assessed the efficiency of analysis methods when the control arm may be retrospectively tested at the time of analysis.

Methods

Analyses considered were (1) the traditional method (random allocation, with all events included), (2) the "intended-effect" method (nested in those individuals who tested positive in both arms and all events therein), and (3) the targeted method (by random allocation but with an endpoint "test-positive event"). These methods are compared using approximate statistical methods and scenario analysis.

Results

Provided t

SUBMITTER: Sasieni P 

PROVIDER: S-EPMC11884843 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature