Cancer chemotherapy in pregnancy and adverse pediatric outcomes: a population-based cohort study.

ABSTRACT:

Background

Administration of chemotherapy during pregnancy is often delayed, while preterm delivery is common. If in utero exposure to chemotherapy is associated with adverse pediatric outcomes, it is unknown whether that relationship is directly attributable to the chemotherapy or is mediated by preterm birth.

Methods

Patients were identified from Canadian cancer registries and administrative data in Alberta, British Columbia, and Ontario, 2003-2017, with follow-up until 2018. The primary exposure was receipt of chemotherapy during pregnancy. Severe neonatal morbidity and mortality (SNM-M), neurodevelopmental disorders and disabilities (NDDs), and pediatric complex chronic conditions (PCCC) reflected short- and long-term pediatric outcomes. Modified Poisson and Cox proporti

SUBMITTER: Metcalfe A 

PROVIDER: S-EPMC11884850 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature