Polygenic risk scores stratify breast cancer risk among women with benign breast disease.

ABSTRACT:

Background

Most breast biopsies are diagnosed as benign breast disease, with 1.5- to 4-fold increased breast cancer risk. Apart from pathologic diagnoses of atypical hyperplasia, few factors aid in breast cancer risk assessment of these patients. We assessed whether a 313-single nucleotide variation (formerly single-nucleotide polymorphism) polygenic risk score stratifies risk of benign breast disease patients.

Methods

We pooled data from 5 Breast Cancer Association Consortium case-control studies (mean age = 59.9 years), including 6706 participants with breast cancer and 8488 participants without breast cancer. Using logistic regression, we estimated breast cancer risk associations by self-reported benign breast disease history and strata of polygenic risk score, with media

SUBMITTER: Sherman ME 

PROVIDER: S-EPMC11884851 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature