Validation of a breast cancer assay for radiotherapy omission: an individual participant data meta-analysis.

ABSTRACT:

Background

There are currently no molecular tests to identify individual breast cancers where radiotherapy (RT) offers no benefit. Profile for the Omission of Local Adjuvant Radiotherapy (POLAR) is a 16-gene molecular signature developed to identify low-risk cancers where RT will not further reduce recurrence rates.

Methods

An individual participant data meta-analysis was performed in 623 patients of node-negative estrogen receptor-positive and HER2-negative early breast cancer enrolled in 3 RT randomized trials for whom primary tumor material was available for analysis. A Cox proportional hazards model on time to locoregional recurrence was used to test the interaction between POLAR score and RT.

Results

A total of 429 (69%) patients' tumors had a high POLAR score, a

SUBMITTER: Karlsson P 

PROVIDER: S-EPMC11884857 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature