Integrated analysis of DNA methylation and transcriptome profiles to identify oxidative stress-related placenta-specific molecules for preeclampsia.

ABSTRACT:

Background

Preeclampsia (PE) is a pregnancy-specific hypertensive disorder and one of the leading causes of maternal mortality. However, its etiology and pathogenesis are not yet fully clarified. This study aimed to uncover methylation-regulated oxidative stress-related placenta-specific molecules in PE.

Methods

Two PE datasets, GSE57767 and GSE25906, were subjected into this study. The oxidative stress-related genes were derived from GeneCards database. Differential methylation and expression analysis were applied to identify methylation-regulated oxidative stress-related genes in PE. The methylation-regulated oxidative stress-related placenta-specific molecules were determined by receiver operating characteristic (ROC) analysis. The single-gene gene set enrichment analysis

SUBMITTER: Xu Y 

PROVIDER: S-EPMC11884871 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature