Central Thalamic Deep Brain Stimulation Modulates Autonomic Nervous System Responsiveness in Disorders of Consciousness.

ABSTRACT:

Background

The heart rate variability (HRV) of patients with disorders of consciousness (DOC) differs from healthy individuals. However, there is rarely research on HRV among DOC patients following treatment with deep brain stimulation (DBS). This study aims to investigate the modulatory effects of DBS-on the central-autonomic nervous system of DOC based on the study of HRV variations.

Methods

We conducted DBS surgery on eight patients with DOC. Postoperatively, all patients underwent short-duration stimulation for 3 days, with stimulation frequencies of 25 Hz, 50 Hz, and 100 Hz respectively. Each day comprised four cycles, with a stimulation duration of 30 min DBS-on and 90 min DBS-off. We obtained the coma recovery scale-revised (CRS-R) scores and synchronously recorded el

SUBMITTER: Cao T 

PROVIDER: S-EPMC11884924 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature