Patent Foramen Ovale and Oxygenation in Patients with Cystic Fibrosis.

ABSTRACT:

Introduction

Patent foramen ovale (PFO) affects about 25% of the population. We studied outcomes in cystic fibrosis (CF).

Methods

We conducted a case-control study of patients with CF (PwCF) and age- and sex-matched controls who underwent agitated saline contrast (bubble) echocardiography, 1998-2020. We assessed PFO impacts using linear, logistic, quasi-Poisson, and Cox proportional hazards models.

Result

Fifty-nine of 64 PwCF and 88 of 93 controls underwent bubble studies to investigate unexplained hypoxemia or dyspnea. PwCF had higher mean pulmonary artery pressure (PAP: 6.9 mm Hg, 95% confidence interval [CI] = 2.35-11.4), reduced tricuspid annular plane systolic excursion (TAPSE: -3.78 mm, CI = -5.64 to -1.93) and similar right ventricular diastolic sizes. Without

SUBMITTER: Belt H 

PROVIDER: S-EPMC11885056 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature