Association of changes in the type 2 diabetes and MASLD/related SLD status with risk of developing cardiovascular disease.

ABSTRACT:

Background & aims

This study assessed the association of remission of type 2 diabetes mellitus (DM) or metabolic dysfunction-associated steatotic liver disease (MASLD)/related SLD (r-SLD; MASLD with excessive alcohol intake) as defined by the fatty liver index with the risk of cardiovascular disease (CVD).

Methods

Health examination data at baseline and after 2 years (2-Years) were extracted from a nationwide claims database in Japan. Among participants aged 18-72 years with at least 3 years of follow-up, 9345 participants with DM-associated MASLD/r-SLD and 71 932 participants with non-DM MASLD/r-SLD at baseline were included in the study. The participants were stratified by the achievement of remission of MASLD/r-SLD or DM at 2-Years. In each group after stratification, the

SUBMITTER: Matsubayashi Y 

PROVIDER: S-EPMC11885070 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature