Impact of TCF7L2 rs7903146 on clinical presentation and risk of complications in patients with type 2 diabetes.

ABSTRACT:

Aims

TCF7L2 rs7903146 is the most impactful single genetic risk variant for type 2 diabetes. However, its role on disease progression, complications and mortality among people with type 2 diabetes at diagnosis remains unclear.

Materials and methods

We assessed the per allele impact of the rs7903146 T-allele on clinical characteristics and complication risk in 9231 individuals with type 2 diabetes at diagnosis and over a 10-year follow-up period. Log-binomial and robust Poisson regression analyses were used to estimate prevalence ratios for clinical characteristics and macro- and microvascular complications at diabetes onset, while Cox regression was applied to estimate the risk of complications post-diagnosis. Analyses were adjusted for sex, calendar year at birth, age at en

SUBMITTER: Hansen AL 

PROVIDER: S-EPMC11885091 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature