Comparison of the in vitro antibiofilm activities of otic cleansers against canine otitis externa pathogens.

ABSTRACT:

Background

Biofilm production by canine otitis externa (COE) pathogens and resistance development to multiple antimicrobials are commonly reported problems in veterinary practice. The use of adjuvants to disrupt biofilms may be a viable adjunctive therapy.

Hypothesis/objectives

To compare the in vitro antibiofilm activity against COE pathogens of three otic cleansers: PHMB-EDTA (poly [hexamethylene] biguanide hydrochloride and disodium edetate), N-acetylcysteine (NAC) and Triz-EDTA.

Animals/isolates

Thirty isolates of each species, including Staphylococcus pseudintermedius, Pseudomonas aeruginosa, Streptococcus canis, Proteus mirabilis, Escherichia coli, and Malassezia pachydermatis, were collected from COE cases and stored at -80°C until tested.

Methods and materi

SUBMITTER: Savaliya BF 

PROVIDER: S-EPMC11885093 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature