Fibroblast growth factor 23 predicts incident diabetic kidney disease: A 4.6-year prospective study.

ABSTRACT:

Aims

Fibroblast growth factor (FGF) 23 is a bone-derived phosphaturic hormone that participates in the regulation of mineral metabolism and the development of chronic kidney disease. This study aimed to investigate the association between FGF23 and diabetic kidney disease (DKD) in a community-based prospective cohort.

Materials and methods

Of 7230 individuals who completed a 4.6-year follow-up survey, 1614 individuals with diabetes at baseline were included in this study. Baseline serum FGF23 levels were measured by enzyme-linked immunosorbent assay. Multiple and ordinal logistic regression analyses were used to examine the predictive performance of baseline FGF23 for incident DKD.

Results

Baseline serum FGF23 levels exhibited an earlier elevation in the course of DKD

SUBMITTER: Liu D 

PROVIDER: S-EPMC11885106 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature