Prognostic significance of the inhibitory-to-stimulatory immune checkpoint ratio in patients with breast cancer.

ABSTRACT:

Background

Accumulating evidences suggested that immune checkpoints (ICPs) played an important role in malignancies including breast cancer (BRCA). We aimed to investigate whether inhibitory-to-stimulatory immune checkpoint ratio (ISICPR) could be used as a prognostic marker for BRCA.

Methods

BRCA patients were enrolled from The Cancer Genome Atlas (TCGA). Survival analysis was performed with Kaplan-Meier (KM) methods. X-tile was used to calculate the optimal cut-off values of ISICPRs. Univariate and multivariate Cox regression analysis were carried out to identify prognostic factors for BRCA patients. Tissue microarray was used to validate our findings.

Results

In total, 586 BRCA patients were collected, including 104 cases of stage I, 330 of stage II, 139 of stage I

SUBMITTER: Tang C 

PROVIDER: S-EPMC11885121 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature