Evaluating the predictive value of clinical models for HBV-related hepatocellular carcinoma: A meta-analysis.

ABSTRACT:

Objectives

Chronic viral hepatitis B (CHB) is a prevalent liver disease with primary hepatic carcinoma (HCC) as a severe complication. Clinical prediction models have gained attention for predicting HBV-related HCC (HBV-HCC). This study aimed to evaluate the predictive value of existing models for HBV-HCC through meta-analysis.

Design

Meta-analysis.

Data sources

Embase, PubMed, the Chinese Biomedical Literature Service System, and the Cochrane database were used for searches between 1970 and 2022.

Methods

A meta-analysis was conducted to assess original studies on HBV-HCC prediction models. The REACH-B, GAGHCC, and CUHCC models were externally validated in a Guangxi cohort. The C-index and calibration curve evaluated 5 years predictive performance, with subgrou

SUBMITTER: Huang L 

PROVIDER: S-EPMC11885123 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature