Prognostic significance and immune microenvironment infiltration patterns of hypoxia and endoplasmic reticulum stress-related genes in gastric cancer.

ABSTRACT:

Background

Gastric cancer (GC) is a prevalent malignant neoplasm within the digestive system, accounting for approximately 740,000 deaths globally each year, significantly impacting patients' quality of life and survival rates. The objective of this investigation was to elucidate the expression patterns of Hypoxia and Endoplasmic Reticulum Stress-related Differentially Expressed Genes (HERSRDEGs) in GC and their association with prognostic outcomes of the patients.

Methods

Utilizing The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases, GC datasets were retrieved, and standard normalization was performed. Differential expression analysis was conducted using DESeq2, while somatic mutations and copy number variations were examined using maftools and GISTIC

SUBMITTER: Li L 

PROVIDER: S-EPMC11885130 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature