Infections and antibiotic use in early childhood have limited importance in developing manifest type 1 diabetes - The ABIS cohort study.

ABSTRACT:

Aims

To investigate the effect of early childhood infections and antibiotic use on the risk of type 1 diabetes in a general population cohort.

Research design and methods

The All Babies In Southeast Sweden (ABIS) cohort followed 16 428 children from birth. Questionnaires collected at 1 year (n=11 093), 3 years (n=8 890) and 5 years of age (n=7 445) included data on infections and antibiotic use and were validated against national registers. After a mean follow-up of 25 years, 168 individuals have been diagnosed with type 1 diabetes (1.0% of the original cohort, aged 1-24.5 years).

Results

There were few significant differences in type or frequency of early childhood infections or antibiotic use between cases with type 1 diabetes and the reference group (remaining indi

SUBMITTER: Belteky M 

PROVIDER: S-EPMC11885132 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature