Metabolically healthy across body mass index categories in relation to serum Klotho levels: a population-based study.

ABSTRACT:

Background

Metabolic health status and body mass index (BMI) are both key predictors of aging-related diseases and premature mortality. However, the relationship between metabolically distinct phenotypes, classified by BMI categories, and serum Klotho levels-a biomarker of aging-remains poorly understood. This study aimed to investigate the association between metabolically healthy phenotypes and serum Klotho levels among middle and aged adults.

Methods

A total of 11,413 participants were included in this study. Participants were categorized into phenotypes according to metabolic disorders and BMI: metabolically healthy and normal weight (MH-NW), metabolically healthy and overweight (MH-OW), metabolically healthy and obesity (MHO), metabolically unhealthy and normal weight (

SUBMITTER: Shu Y 

PROVIDER: S-EPMC11885134 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature