Efficacy and safety of water-free topical cyclosporine for moderate to severe dry eye disease: a systematic review and meta-analysis.

ABSTRACT:

Background

Dry eye disease (DED) is a widely prevalent ocular symptom, with an estimated global prevalence of around 12%. The increasing prevalence of this disease among adults poses a significant morbidity burden. The aim of this study is to analyze the efficacy and safety of water-free cyclosporine, a new intervention suggested to be more effective in treating DED.

Methods

A comprehensive literature search was conducted using databases as PubMed, Cochrane, Scopus and Web of Science. Keywords used include "dry eye", "water-free cyclosporine", and "DED" among others. Randomized controlled trials (RCTs) evaluating the use of water-free cyclosporine in patients with dry eye disease were included.

Results

A total of 4 RCTs were included in our analysis, consisting of 1,4

SUBMITTER: Rehan AH 

PROVIDER: S-EPMC11885208 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature