The dual role of circHIPK3 in cancer and its implications for multiple drugs resistance: a systematic review and computational approach.

ABSTRACT:

Background

circHIPK3 role in cancer as oncogene or tumor suppressor is still debated, therefore, this study aimed to understand the dual role of this circRNA in different cancers. Furthermore, all available evidence of circHIPK3 interactions with sponged-miRNA and RBPs in oncological diseases were systematically gathered to better understand the its functional role in cancer.

Methods

PubMed, BioMedCentral, Web of Science, Embase and Scopus databases were searched for articles published until October 2024, following the PRISMA guideline. In computational analysis, miRNAs' sponged target genes and RBPs were used for gene enrichment in KEGG, REACTOME and Gene Ontology, and TISSUES expression. miRTargetLink 2.0 was used to search for target genes, and STRING v.12.0 for gene enri

SUBMITTER: Campelo MM 

PROVIDER: S-EPMC11885226 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature